cDNA cloning of MAP kinase kinase reveals kinase cascade pathways in yeasts to vertebrates.
نویسندگان
چکیده
منابع مشابه
MAP kinase pathways.
Mitogen-activated protein kinase (MAPK) modules containing three sequentially activated protein kinases are key components of a series of vital signal transduction pathways that regulate processes such as cell proliferation, cell differentiation, and cell death in eukaryotes from yeast to humans (Fig. 1) (Qi and Elion 2005; Raman et al. 2007; Keshet and Seger 2010). Each cascade is initiated by...
متن کاملMAP kinase pathways.
Mitogen-activated protein kinase (MAPK) pathways regulate diverse processes ranging from proliferation and differentiation to apoptosis. Activated by an enormous array of stimuli, they phosphorylate numerous proteins, including transcription factors, cytoskeletal proteins, kinases and other enzymes, and greatly influence gene expression, metabolism, cell division, cell morphology and cell survi...
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Abstract. Ordinary Differential Equations (ODEs) represent a powerful technique for analysing biological systems. ODEs can cope with large numbers of components involved in multiple interactions. ODEs also bring a certain level of complexity through the reactions and the combinations of components within these reactions. Using the MitogenActivated Protein (MAP) Kinase cascade, it will be shown ...
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The MAP kinase cascade is a network of enzymatic reactions arranged in layers. In each layer occurs a multiple futile cycle of phosphorylations. The fully phosphorylated substrate then serves as an enzyme for the layer below. This paper focusses on the existence of parameters for which Hopf bifurcations occur and generate periodic orbits. Furthermore it is explained how geometric singular pertu...
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A continuing focus of our work has been an effort to understand the signal transduction pathways through which insulin achieves its cellular actions. In the mid-1970s, we and others observed that insulin promoted an increase in Ser/Thr phosphorylation of a subset of cellular proteins. This finding was unanticipated, inasmuch as nearly all of the actions of insulin then known appeared to result ...
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ژورنال
عنوان ژورنال: The EMBO Journal
سال: 1993
ISSN: 0261-4189
DOI: 10.1002/j.1460-2075.1993.tb05713.x